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, 9 (1), 69-73

Molecular Cloning and Sequencing of the Rat interleukin-12 p40 Gene

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  • PMID: 9613680

Molecular Cloning and Sequencing of the Rat interleukin-12 p40 Gene

J Khalife et al. Eur Cytokine Netw.

Abstract

The nucleotide sequences containing the rat interleukin-12 p40 gene was determined. Sequencing revealed the presence of six exons and five introns. Analysis of the 5' non-coding region showed the presence of several possible sites involved in cytokine gene regulation at the transcriptional level. Comparison of the deduced amino acid sequence of rat IL-12 p40 with that of the mouse and of human p40, showed 92% and 65% identity respectively.

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