Sea-blue histiocyte syndrome in bone marrow secondary to total parenteral nutrition

Leuk Lymphoma. 1998 Feb;28(5-6):523-9. doi: 10.3109/10428199809058360.


Clinical and hematological abnormalities can occur in patients receiving intravenous fat emulsions as part of a long-term parenteral nutrition; they consist of hepatosplenomegaly and peripheral blood cytopenia(s). These abnormalities lead to bone marrow examination which revealed numerous macrophages laden with blue staining pigment granules and separate lipid vacuoles, presenting the typical histochemical characteristics of sea-blue histiocytes. Thus, long-term parenteral nutrition including fat-emulsion sources may represent a further condition in addition to the wide variety of disorders which can be associated with sea-blue histiocytosis. Moreover, in view of its clinical and morphological presentation, this storage pathological state could be compared with the so-called sea-blue histiocyte syndrome described by Silverstein and colleagues.

Publication types

  • Review

MeSH terms

  • Bone Marrow / pathology
  • Bone Marrow / physiopathology
  • Bone Marrow Diseases / etiology*
  • Bone Marrow Diseases / pathology*
  • Bone Marrow Diseases / physiopathology*
  • Fats / administration & dosage
  • Fats / adverse effects
  • Humans
  • Parenteral Nutrition, Total / adverse effects*
  • Sea-Blue Histiocyte Syndrome / etiology*
  • Sea-Blue Histiocyte Syndrome / pathology*
  • Sea-Blue Histiocyte Syndrome / physiopathology*


  • Fats