Preliminary evidence for a beneficial effect of low-frequency, repetitive transcranial magnetic stimulation in patients with major depression and schizophrenia

Depress Anxiety. 1998;7(2):65-8.


Objective: This study was designed to evaluate the potential efficacy of repetitive transcranial magnetic stimulation (rTMS) at low-frequency in patients with major depression and schizophrenia.

Experimental design: We investigated the therapeutic effect of a course of 10 rTMS sessions in 14 subjects with major depression (MD) and 10 with schizophrenia.

Principal observations: Seven of the depressed patients reported significant improvement in depressive symptomatology, and seven of the schizophrenic subjects reported amelioration of anxiety and restlessness.

Conclusions: These preliminary results suggest that low-frequency rTMS may be beneficial mainly in MD and to some extent in schizophrenia, and support the need for controlled studies to further validate its therapeutic potential.

MeSH terms

  • Adult
  • Aged
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / psychology
  • Depressive Disorder, Major / therapy*
  • Electromagnetic Fields*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prefrontal Cortex
  • Psychiatric Status Rating Scales
  • Schizophrenia / diagnosis
  • Schizophrenia / therapy*
  • Schizophrenic Psychology
  • Treatment Outcome