Theanine-induced Reduction of Brain Serotonin Concentration in Rats

Biosci Biotechnol Biochem. 1998 Apr;62(4):816-7. doi: 10.1271/bbb.62.816.

Abstract

Following the administration of theanine, the brain tryptophan content significantly increased or tended to increase, but the contents of serotonin and 5-hydroxyindole acetic acid (5HIAA) decreased. The use of inhibitors of serotonin metabolism enable us to speculate that theanine reduced serotonin synthesis and also increased serotonin degradation in the brain.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects*
  • Fenclonine / pharmacology
  • Glutamates / pharmacology*
  • Hydroxyindoleacetic Acid / metabolism
  • Male
  • Monoamine Oxidase Inhibitors / pharmacology
  • Pargyline / pharmacology
  • Rats
  • Rats, Wistar
  • Serotonin / metabolism*
  • Serotonin Antagonists / pharmacology
  • Tryptophan / metabolism

Substances

  • Glutamates
  • Monoamine Oxidase Inhibitors
  • Serotonin Antagonists
  • Serotonin
  • Hydroxyindoleacetic Acid
  • theanine
  • Tryptophan
  • Pargyline
  • Fenclonine