Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor

Science. 1998 Jun 5;280(5369):1618-20. doi: 10.1126/science.280.5369.1618.


A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin; it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alphaherpesvirinae / physiology*
  • Animals
  • Base Sequence
  • CHO Cells
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / physiology*
  • Cells, Cultured
  • Cricetinae
  • Epithelial Cells / virology
  • Gene Expression
  • Herpesvirus 1, Bovine / physiology
  • Herpesvirus 1, Human / physiology*
  • Herpesvirus 1, Suid / physiology
  • Herpesvirus 2, Human / physiology*
  • Humans
  • Membrane Proteins*
  • Molecular Sequence Data
  • Nectins
  • Neurons / virology
  • Polymerase Chain Reaction
  • Receptors, Virus*
  • Transfection
  • Tumor Cells, Cultured
  • Viral Envelope Proteins / metabolism


  • Cell Adhesion Molecules
  • Membrane Proteins
  • Nectins
  • Receptors, Virus
  • Viral Envelope Proteins
  • glycoprotein D, Human herpesvirus 1
  • glycoprotein D-herpes simplex virus type 2
  • poliovirus receptor

Associated data

  • GENBANK/AF060231