A model of perinatal hypoxic-ischemic brain damage

Ann N Y Acad Sci. 1997 Dec 19;835:234-49. doi: 10.1111/j.1749-6632.1997.tb48634.x.


In conclusion, our immature rat model has gained wide acceptance as the animal model of choice to study basic physiologic, biochemical, and molecular mechanisms of perinatal hypoxic-ischemic brain damage. In addition, the model has been used extensively to study those physiologic and therapeutic variables which either are deleterious or beneficial to the perinatal brain undergoing hypoxia-ischemia. As therapeutic interventions are tested in the animal setting, the results will provide important information regarding the effect of these agents in the human setting.

Publication types

  • Review

MeSH terms

  • Animals
  • Animals, Newborn*
  • Asphyxia / physiopathology
  • Brain Ischemia / physiopathology*
  • Disease Models, Animal*
  • Humans
  • Hypoxia, Brain / physiopathology*
  • Infant, Newborn
  • Infant, Newborn, Diseases / physiopathology*
  • Rats