Relations of nm23 expression to clinicopathologic variables and proliferative activity of gastric cancer lesions

Cancer Detect Prev. 1998;22(3):246-50. doi: 10.1046/j.1525-1500.1998.0oa27.x.


Relationships of nm23 expression and 12 clinicopathologic variables and proliferative activity of cancer cells were examined in 55 gastric cancer patients to clarify the effects of nm23 expression on the factors and activity in gastric cancer. Expression of nm23 was determined by immunohistochemically stained sections using a monoclonal antibody, nm23H-1. Proliferative activity was immunohistochemically evaluated by proliferating cell nuclear antigen (PCNA) labeling index (LI) using a monoclonal antibody PC10. Expression of nm23 was found in 24 lesions (positive group) but not in 31 lesions (negative group). With regard to clinicopathologic variables, a significant (p < 0.05) difference between the positive and negative groups was found in 1 of the 12 factors, depth of cancer invasion. PCNA LI (48.9 +/- 11.6%) of the former group was significantly (p < 0.05) higher than that (40.3 +/- 12.6%) ot the latter, although multiple regression analysis showed that nm23 expression was not one of the most influencing variables for PCNA LI. The results may suggest that expression of nm23 in gastric cancer lesions is correlated to tumor progression and/or proliferation rather than suppression of metastasis.

Publication types

  • Review

MeSH terms

  • Aged
  • Biomarkers, Tumor / biosynthesis*
  • Cell Division
  • Humans
  • Middle Aged
  • Monomeric GTP-Binding Proteins*
  • NM23 Nucleoside Diphosphate Kinases
  • Nucleoside-Diphosphate Kinase*
  • Proliferating Cell Nuclear Antigen / analysis
  • Regression Analysis
  • Stomach Neoplasms / chemistry
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / pathology*
  • Transcription Factors / biosynthesis*


  • Biomarkers, Tumor
  • NM23 Nucleoside Diphosphate Kinases
  • Proliferating Cell Nuclear Antigen
  • Transcription Factors
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • Monomeric GTP-Binding Proteins