A novel method of assessing carcinoma cell proliferation by biophoton emission

Cancer Lett. 1998 May 15;127(1-2):155-60. doi: 10.1016/s0304-3835(98)00064-0.


Changes in the emission intensities of ultraweak biophoton emission during the cell proliferation of human carcinoma cell culture (TE9 cell line) were detected using a highly sensitive and low noise measurement apparatus coupled with a flow culture system. In the sampling period of 93 h, the biophoton emission intensity from the culture followed a similar course as that of the growth curve. Spectral analysis of the biophoton emission from the cell culture demonstrated a significant peak at around 530 nm. Our results suggest that the emission intensity mainly depends on the cell population and that this noninvasive technique has a potential role in cancer diagnosis.

MeSH terms

  • Carcinoma / pathology*
  • Cell Division
  • Esophageal Neoplasms / pathology*
  • Humans
  • Luminescent Measurements*
  • Photons*