99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo

Nucl Med Biol. 1998 Apr;25(3):233-40. doi: 10.1016/s0969-8051(97)00201-1.


The aim of this study was to compare uptake of 99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and biodistribution in vivo in rats. In vitro, uptake decreased in the order MIBI-->tetrofosmin-->Q12. Uptake of MIBI and tetrofosmin, but not of Q12, in cultured tumor cells was dependent on the plasma membrane and mitochondrial potential. In vivo, heart uptake of all three compounds was high and stable. Tumor uptake decreased in the order MIBI-->Q12-->tetrofosmin and the tumor/blood ratio in the order MIBI-->tetrofosmin-->Q12.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Biological Transport
  • Breast Neoplasms
  • Cell Membrane / physiology
  • Female
  • Furans / pharmacokinetics*
  • Humans
  • Kinetics
  • Male
  • Mitochondria / physiology
  • Myocardium / metabolism
  • Organophosphorus Compounds / pharmacokinetics*
  • Organotechnetium Compounds / pharmacokinetics*
  • Radiopharmaceuticals / pharmacokinetics*
  • Rats
  • Rats, Wistar
  • Technetium Tc 99m Sestamibi / pharmacokinetics*
  • Tissue Distribution
  • Tumor Cells, Cultured


  • Furans
  • Organophosphorus Compounds
  • Organotechnetium Compounds
  • Radiopharmaceuticals
  • technetium Tc 99m Q12
  • technetium tc-99m tetrofosmin
  • Technetium Tc 99m Sestamibi