TGF-beta in the central nervous system: potential roles in ischemic injury and neurodegenerative diseases

Cytokine Growth Factor Rev. 1997 Dec;8(4):267-92. doi: 10.1016/s1359-6101(97)00018-x.


The Transforming Growth Factor-betas (TGF-beta) are a group of multifunctional proteins whose cellular sites of production and action are widely distributed throughout the body, including the central nervous system (CNS). Within the CNS, various isoforms of TGF-beta are produced by both glial and neural cells. When evaluated in either cell culture or in vivo models, the various isoforms of TGF-beta have been shown to have potent effects on the proliferation, function, or survival of both neurons and all three glial cell types, astrocytes, microglia and oligodendrocytes. TGF-beta has also been shown to play a role in several forms of acute CNS pathology including ischemia, excitotoxicity and several forms of neurodegenerative diseases including multiple sclerosis, Parkinson's disease, AIDS dementia and Alzheimer's disease.

Publication types

  • Review

MeSH terms

  • AIDS Dementia Complex / etiology
  • Alzheimer Disease / etiology
  • Animals
  • Astrocytes / physiology
  • Central Nervous System / blood supply*
  • Central Nervous System / injuries
  • Central Nervous System / physiology*
  • Encephalomyelitis, Autoimmune, Experimental / drug therapy
  • Encephalomyelitis, Autoimmune, Experimental / etiology
  • Gene Expression
  • Humans
  • Ischemia / etiology*
  • Ischemia / genetics
  • Ischemia / physiopathology
  • Microglia / physiology
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / physiopathology
  • Neurodegenerative Diseases / etiology*
  • Neurodegenerative Diseases / physiopathology
  • Oligodendroglia / physiology
  • Parkinson Disease / drug therapy
  • Parkinson Disease / etiology
  • Transforming Growth Factor beta / administration & dosage
  • Transforming Growth Factor beta / genetics
  • Transforming Growth Factor beta / physiology*


  • Transforming Growth Factor beta