[The effect of nootropic agents on brain mitochondrial function in the dynamics of craniocerebral trauma from the age aspect]

Eksp Klin Farmakol. Mar-Apr 1998;61(2):65-8.
[Article in Russian]

Abstract

A craniocerebral trauma was modelled in experiments on one-month-old rats. Oxidative phosphorylation in the brain mitochondria was studied by polarography 1, 4, 7 days and 4 weeks after the trauma. In the posttraumatic period the animals received piracetam (1 g/kg), picamilon (500 mg/kg), pyriditol (100 mg/kg), pantogam (160 mg/kg), ACTH (5-10) (0.1 mg/kg), nooglutyl (25 mg/kg), and GVS (0.5 mg/kg). It was found that piracetam, picamilon, and nooglutyl have a protective effect on the function of the brain mitochondria during the course of a craniocerebral trauma. Nooglutyl surpasses all the other drugs in its influence on the effectiveness of oxidative phosphorylation of mitochondria in immature rats in the posttraumatic period.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Aging / drug effects*
  • Aging / metabolism
  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Brain Injuries / metabolism*
  • Energy Metabolism / drug effects
  • Female
  • Male
  • Mitochondria / drug effects*
  • Mitochondria / metabolism
  • Nootropic Agents / pharmacology*
  • Oxidative Phosphorylation / drug effects
  • Rats
  • Time Factors

Substances

  • Nootropic Agents