Enteroaggregative Escherichia Coli

Emerg Infect Dis. Apr-Jun 1998;4(2):251-61. doi: 10.3201/eid0402.980212.


Enteroaggregative Escherichia coli (EAEC), an increasingly recognized cause of diarrhea in children in developing countries, has been particularly associated with persistent diarrhea (more than 14 days), a major cause of illness and death. Recent outbreaks implicate EAEC as a cause of foodborne illness in industrialized countries. The pathogenesis of EAEC infection is not well understood, but a model can be proposed in which EAEC adhere to the intestinal mucosa and elaborate enterotoxins and cytotoxins, which result in secretory diarrhea and mucosal damage. EAEC's ability to stimulate the release of inflammatory mediators may also play a role in intestinal illness.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacterial Adhesion
  • Diarrhea / microbiology*
  • Disease Outbreaks
  • Enterotoxins / metabolism
  • Escherichia coli / pathogenicity*
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Infections / pathology
  • Humans
  • Intestinal Mucosa / microbiology
  • Intestinal Mucosa / pathology


  • Enterotoxins