Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene

J Hum Genet. 1998;43(2):132-4. doi: 10.1007/s100380050054.


Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activin Receptors, Type II
  • Chromosome Mapping
  • Chromosome Walking
  • Chromosomes, Human, Pair 3 / genetics*
  • DNA, Neoplasm / genetics
  • Exons / genetics
  • Genes*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lung Neoplasms / genetics
  • Receptors, Growth Factor / genetics*
  • Sequence Deletion


  • DNA, Neoplasm
  • Receptors, Growth Factor
  • Activin Receptors, Type II

Associated data

  • GENBANK/AB008681