[A revolutionary Japanese method for treatment of lymphangioma]

Lakartidningen. 1998 Apr 29;95(18):2074-7.
[Article in Swedish]


Large cystic lymphangiomas of the neck (hygroma colli) have traditionally been treated surgically or by local injection of various sclerosing agents. Owing to the infiltrative growth of these cysts, radical surgery has often been difficult due to the risk of damage to nerves and adjacent organs; and the use of available sclerosing agents has often resulted in disfigurement due to extensive scarring, thus rendering secondary surgery even more difficult. However, OK-432, a new agent for local injection, has been tested with good results, especially in Japan. In five consecutive paediatric cases of lymphangioma, we found ultrasound-guided injection of the cysts with OK-432 to yield good response without complications. In three cases, the lymphangioma disappeared leaving the child's appearance quite normal, and there has been no recurrence. In one case, the lymphangioma disappeared but apparently recurred within half a year (during which time we had lost contact with the family). This was the only case of small cysts (cavernous lymphangioma), which are putatively more resistant to OK-432. The only child to be operated also had thoracic lymphangioma which was not injected, though the cervical part which was injected was reduced by 50 per cent pre-operatively, the final outcome being excellent with no visible cysts in any region. Thus, hitherto our results suggest the therapeutic effect of OK-432 to be good, and further clinical investigation is planned.

Publication types

  • Clinical Trial

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / adverse effects
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Injections / methods
  • Japan
  • Lymphangioma, Cystic / diagnostic imaging
  • Lymphangioma, Cystic / drug therapy*
  • Male
  • Picibanil / administration & dosage*
  • Picibanil / adverse effects
  • Radiography
  • Sweden
  • Ultrasonography


  • Antineoplastic Agents
  • Picibanil