Role of Crk oncogene product in physiologic signaling

Crit Rev Oncog. 1997;8(4):329-42. doi: 10.1615/critrevoncog.v8.i4.30.


v-Crk is a member of the family of adaptor-type signaling molecules that consist mostly of SH2 and SH3 domains. The cellular homologs of v-Crk includes CrkI, CrkII, and CrkL; these have been isolated from species ranging from lower vertebrates to man. Crk-family proteins are involved in a variety of signaling cascades such as those of growth factor receptor, integrin, T-cell receptor, B-cell antigen receptor, and cytokines. It has been postulated that the primary function of Crk is to recruit cytoplasmic proteins in the vicinity of tyrosine kinases through SH2-phosphotyrosine interaction. Thus, the output from Crk depends on the SH3-binding proteins, which include the C3G guanine nucleotide exchange protein for Rap1, Abl tyrosine kinase, DOCK180, and the Sos guanine nucleotide exchange protein for Ras. The variety of the Crk-binding proteins indicate the pleiotropic function of Crk.

Publication types

  • Review

MeSH terms

  • Animals
  • ErbB Receptors / metabolism
  • Humans
  • Integrins / physiology
  • Models, Chemical
  • Oncogene Protein v-crk
  • Oncogenes
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Cell Surface / physiology
  • Retroviridae Proteins, Oncogenic / physiology*
  • Signal Transduction*
  • Vertebrates
  • src Homology Domains


  • Integrins
  • Oncogene Protein v-crk
  • Receptors, Cell Surface
  • Retroviridae Proteins, Oncogenic
  • ErbB Receptors
  • Protein-Tyrosine Kinases