Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury

Brain Res. 1998 Jun 8;795(1-2):1-9. doi: 10.1016/s0006-8993(98)00247-9.

Abstract

Neurotoxic injury of the caudate-putamen and lateral globus pallidus unilaterally initiated transneuronal degeneration of neurons in the ipsilateral substantia nigra reticulata (SNR). Quantification of SNR neurons using unbiased stereology demonstrated that neuron loss began 4 days after the initial striatal lesion, followed by significant loss (50%) at 6 days and a plateau at 8 days. Analysis at the light and ultrastructural levels revealed morphological changes consistent with a type of programmed cell death. These temporal and histological results refine an in vivo model in which to explore mechanisms of delayed neuronal degeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Count
  • Corpus Striatum / pathology*
  • Excitatory Amino Acid Agonists
  • Ibotenic Acid
  • Male
  • Microscopy, Electron
  • Nerve Degeneration / chemically induced
  • Nerve Degeneration / pathology*
  • Neurons / cytology
  • Neurons / ultrastructure
  • Neurotoxins
  • Rats
  • Rats, Wistar
  • Substantia Nigra / pathology*

Substances

  • Excitatory Amino Acid Agonists
  • Neurotoxins
  • Ibotenic Acid