The use of matrices in calculating mendelian probabilities

Ann Hum Genet. 1976 Jul;40(1):37-54. doi: 10.1111/j.1469-1809.1976.tb00163.x.


It is shown that the method of calculation of probabilities for genetic counselling developed by Bolling, Chase and Murphy can be generalized to give the relative probabilities for any single individual in any pedigree for any mendelian condition. The calculations only require matrix multiplications (of one kind or another), and the expressions can be written down and evaluated directly, whether by hand or by computer.

MeSH terms

  • Female
  • Genes, Dominant
  • Genetics, Medical*
  • Genotype
  • Humans
  • Male
  • Pedigree
  • Probability*