Maintenance of growth in cystic fibrosis despite reduction in pancreatic enzyme supplementation

Arch Dis Child. 1998 Apr;78(4):377-8. doi: 10.1136/adc.78.4.377.


Twenty one children with cystic fibrosis were advised to decrease their pancreatic enzyme supplement (PES) dose to less than 10,000 units lipase/kg/day. Mean PES dosage was significantly decreased in 15 patients from 18,380 to 8647 units lipase/kg/day. There were no significant changes in energy or fat intake, but there were significant increases in weight SD score, height SD score, and weight/height ratio.

MeSH terms

  • Child
  • Child, Preschool
  • Cystic Fibrosis / drug therapy*
  • Cystic Fibrosis / metabolism
  • Cystic Fibrosis / physiopathology
  • Drug Administration Schedule
  • Feces / chemistry
  • Follow-Up Studies
  • Growth / drug effects*
  • Humans
  • Lipase / administration & dosage*
  • Lipids / analysis


  • Lipids
  • Lipase