Association of cystic fibrosis with allergy

Arch Dis Child. 1976 Jul;51(7):507-11. doi: 10.1136/adc.51.7.507.


Immediate skin hypersensitivity to various inhalant allergens was present in 59% of 123 children with cystic fibrosis (CF), a much higher percentage than in the general population. This is consistent with the idea that atopy arises as a result of impaired handling of antigen at mucosal surfaces. The allergic CF children had more chest infections, a worse chest x-ray appearance, and lower peak expiratory flow rates. Allergic diseases were also frequent in the CF obligate heterozygotes (32% of mothers and 26% of fathers). It is suggested that the heterozygotes may also have a mucosal abnormality resulting in defective antigen handling.

MeSH terms

  • Adolescent
  • Allergens
  • Aspergillus / immunology
  • Breast Feeding
  • Child
  • Cladosporium / immunology
  • Cystic Fibrosis / complications*
  • Female
  • Humans
  • Hypersensitivity / complications*
  • Hypersensitivity / genetics
  • Hypersensitivity, Immediate
  • Infant
  • Intradermal Tests
  • Lung Volume Measurements
  • Male
  • Peak Expiratory Flow Rate
  • Respiratory Tract Infections / complications
  • Rhinitis, Allergic, Seasonal / complications


  • Allergens