Long-term assessment of children exposed in utero to carbimazole

Arch Dis Child. 1976 Jul;51(7):532-6. doi: 10.1136/adc.51.7.532.

Abstract

Twenty-five children aged 3 to 13 years who had been exposed in utero to carbimazole were assessed physically and psychologically to evaluate the long-term effects of the drug on growth and development. 2 children had congenital malformations but all had normal pituitary-thyroid function and appeared to have grown and developed normally.

MeSH terms

  • Abnormalities, Drug-Induced
  • Adolescent
  • Body Constitution
  • Carbimazole / adverse effects*
  • Carbimazole / therapeutic use
  • Cataract / etiology
  • Child
  • Child Behavior Disorders / etiology
  • Child, Preschool
  • Female
  • Fetus / drug effects*
  • Follow-Up Studies
  • Humans
  • Hyperthyroidism / drug therapy
  • Intelligence
  • Limb Deformities, Congenital
  • Male
  • Maternal-Fetal Exchange
  • Pituitary Gland / drug effects*
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Thyroid Function Tests
  • Thyroid Gland / drug effects*

Substances

  • Carbimazole