Idiopathic midline destructive disease--does it exist?

J Laryngol Otol. 1998 Mar;112(3):307-9. doi: 10.1017/s002221510015844x.


There is controversy whether idiopathic mid-line destructive disease remains a valid entity, some authors considering that such cases are unrecognized malignant lymphoma or Wegener's disease. A case is presented in which numerous nasal biopsies over several years failed to show evidence of either lymphoma or Wegener's disease. Molecular genetic analysis of archival tissue did not demonstrate a monoclonal lymphoid population. It is proposed that idiopathic mid-line destructive disease remains a valid description in a small number of cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Granuloma, Lethal Midline / classification
  • Granuloma, Lethal Midline / pathology*
  • Humans
  • Nose Deformities, Acquired / pathology
  • Terminology as Topic