Efficacies of zinc-finger-active drugs against Giardia lamblia

Antimicrob Agents Chemother. 1998 Jun;42(6):1488-92. doi: 10.1128/AAC.42.6.1488.

Abstract

Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 microM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 +/- 0.32 microM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

MeSH terms

  • Animals
  • Antiprotozoal Agents / pharmacology*
  • Antiprotozoal Agents / therapeutic use
  • Disease Models, Animal
  • Disulfiram / pharmacology*
  • Disulfiram / therapeutic use
  • Drug Evaluation, Preclinical
  • Giardia lamblia / drug effects*
  • Giardiasis / drug therapy
  • Mice
  • Zinc Fingers / drug effects*

Substances

  • Antiprotozoal Agents
  • Disulfiram