Characterization of the 6'-N-aminoglycoside acetyltransferase gene aac(6')-Iq from the integron of a natural multiresistance plasmid

Antimicrob Agents Chemother. 1998 Jun;42(6):1506-8. doi: 10.1128/AAC.42.6.1506.

Abstract

The nucleotide sequence of a newly identified amikacin resistance gene, aac(6')-Iq (551 bp), is reported. It has 68.4 and 94.4% homology with the aac(6')-Ia gene and the recently described aac(6')-Ip gene, respectively. Analysis of its flanking sequences indicated that it is in the first cassette of a class I integron and has an attC site (59-base element) 108 bp in length.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetyltransferases / genetics*
  • Acetyltransferases / metabolism
  • Amikacin / pharmacology
  • Amino Acid Sequence
  • Anti-Bacterial Agents / pharmacology
  • Base Sequence
  • Drug Resistance, Multiple / genetics*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics*
  • Molecular Sequence Data
  • Plasmids / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • Anti-Bacterial Agents
  • Amikacin
  • Acetyltransferases
  • aminoglycoside N(6')-acetyltransferase

Associated data

  • GENBANK/AF047556