A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine

Burns. 1998 Mar;24(2):157-61. doi: 10.1016/s0305-4179(97)00113-7.


Histological and clinical studies of wound healing have been made on comparable fresh partial thickness burns with honey dressing or silver sulfadiazine (SSD) in two groups of 25 randomly allocated patients. Of the wounds treated with honey 84 per cent showed satisfactory epithelialization by the 7th day, and in 100 per cent of the patients by the 21st day. In wounds treated with silver sulfadiazine, epithelialization occurred by the 7th day in 72 per cent of the patients and in 84 per cent of patients by 21 days. Histological evidence of reparative activity was seen in 80 per cent of wounds treated with the honey dressing by the 7th day with minimal inflammation. Fifty two per cent of the silver sulfadiazine treated wounds showed reparative activity with inflammatory changes by the 7th day. Reparative activity reached 100 per cent by 21 days with the honey dressing and 84 per cent with SSD. Thus in honey dressed wounds, early subsidence of acute inflammatory changes, better control of infection and quicker wound healing was observed while in the SSD treated wounds sustained inflammatory reaction was noted even on epithelialization.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Topical
  • Adolescent
  • Adult
  • Anti-Infective Agents, Local / administration & dosage
  • Anti-Infective Agents, Local / therapeutic use*
  • Bandages
  • Burns / drug therapy*
  • Burns / pathology
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Honey*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Silver Sulfadiazine / administration & dosage
  • Silver Sulfadiazine / therapeutic use*
  • Skin / drug effects
  • Skin / pathology
  • Treatment Outcome
  • Wound Healing / drug effects*


  • Anti-Infective Agents, Local
  • Silver Sulfadiazine