Human immunodeficiency virus-2 infection in baboons is an animal model for human immunodeficiency virus pathogenesis in humans

Arch Pathol Lab Med. 1998 Jun;122(6):523-33.


Objective: To assess disease progression in baboons (Papio cynocephalus) that were infected with two human immunodeficiency virus-2 (HIV-2) isolates.

Methods: Eight baboons were inoculated intravenously with either HIV-2UC2 or HIV-2UC14 and were followed for a 2- to 7-year period of observation.

Results: Six of 8 baboons showed lymphadenopathy and other signs of HIV-related disease, 3 of 8 baboons had an acute phase CD4+ T-cell decline, and 2 of 5 baboons infected with the HIV-2UC2 isolate progressed to an acquired immunodeficiency syndrome-like disease. Human immunodeficiency virus-2-specific pathology in lymphatic tissues included follicular lysis, vascular proliferation, and lymphoid depletion. Both neutralizing antibodies and a CD8+ T-cell antiviral response were associated with resistance to disease.

Conclusions: Disease progression and the development of acquired immunodeficiency syndrome in HIV-2-infected baboons have similarities to human HIV infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / pathology
  • Animals
  • Antibodies, Viral / analysis
  • CD4 Lymphocyte Count
  • CD8-Positive T-Lymphocytes / immunology
  • Disease Models, Animal
  • Disease Progression
  • Female
  • Fibroma / pathology
  • HIV Infections / etiology*
  • HIV Infections / pathology
  • HIV Infections / physiopathology
  • HIV-2* / immunology
  • HIV-2* / isolation & purification
  • HIV-2* / pathogenicity
  • Humans
  • In Situ Hybridization
  • Lymphatic Diseases / pathology
  • Male
  • Neutralization Tests
  • Papio / virology
  • RNA, Viral / analysis
  • Sarcoma, Kaposi / pathology
  • Virus Replication / immunology


  • Antibodies, Viral
  • RNA, Viral