Indomethacin-induced delayed fracture healing

Arch Orthop Unfallchir. 1976 Jul 23;85(2):151-4. doi: 10.1007/BF00415452.


A patient with an ankle joint fracture-dislocation was preoperatively treated with indomethacin. As in previous animal experiments, indomethacin was found to have an inhibitory effect on bone formation. It is suggested that indomethacin should be used with caution if periosteal fracture healing is anticipated.

Publication types

  • Case Reports

MeSH terms

  • Ankle
  • Bone Regeneration / drug effects*
  • Bony Callus / drug effects
  • Fracture Fixation, Internal / methods*
  • Humans
  • Indomethacin / pharmacology*
  • Male
  • Middle Aged
  • Osteoblasts
  • Time Factors
  • Wound Healing / drug effects*


  • Indomethacin