Implementation and evaluation of a new pulse sequence for rapid acquisition of double inversion recovery images for simultaneous suppression of white matter and CSF

J Magn Reson Imaging. 1998 May-Jun;8(3):544-7. doi: 10.1002/jmri.1880080305.


We describe a fast double inversion recovery (DIR) imaging sequence that effectively attenuates signal from both white matter and cerebrospinal fluid (CSF). The pulse sequence uses a novel inversion/excitation scheme and fast spin-echo readout to maximize scan efficiency. The white matter/CSF suppressed images can be acquired from the entire brain in approximately 6 minutes. Evaluation of the fast DIR sequence on patients with multiple sclerosis (MS) demonstrates high lesion conspicuity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain / pathology*
  • Cerebrospinal Fluid*
  • Computer Systems
  • Echo-Planar Imaging / instrumentation
  • Humans
  • Image Enhancement / instrumentation*
  • Image Processing, Computer-Assisted / instrumentation*
  • Magnetic Resonance Imaging / instrumentation*
  • Multiple Sclerosis / diagnosis*
  • Sensitivity and Specificity
  • Software