Efficacy of oral magnesium administration on decreased exercise tolerance in a state of chronic sleep deprivation

Jpn Circ J. 1998 May;62(5):341-6. doi: 10.1253/jcj.62.341.


We have previously reported that chronic sleep deprivation causes a deficiency of intracellular magnesium (Mg) and decreased exercise tolerance. The aim of this study was to clarify whether oral administration of Mg could be effective in restoring the exercise tolerance that is decreased by chronic sleep deprivation. A bicycle ergometer cardiopulmonary exercise test was performed by 16 healthy volunteers (mean age 21.9 years). They were divided into 2 groups: 8 received doses of 100 mg of Mg orally per day for 1 month (Mg group) and the remaining 8 received no Mg and served as the control group. The study conditions were designed as follows: (1) the usual state (good sleep); and (2) the sleep-deprived state (sleeping time up to 60% less than the usual state for 1 month). The ratio of intracellular Mg content of the sleep-deprived state to the usual sleep state was significantly higher in the Mg group (p<0.05) than the untreated control group. There was no difference between the sleep-deprived state and the usual state with regard to anaerobic threshold and peak oxygen uptake in the Mg group, whereas both of these decreased in the sleep-deprived state in the control group. These results indicate that decreased exercise tolerance observed in the sleep-deprived state could be improved by oral Mg administration.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Calcium / blood
  • Chronic Disease
  • Erythrocytes / chemistry
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism
  • Exercise / physiology
  • Exercise Tolerance / drug effects*
  • Exercise Tolerance / physiology*
  • Fatigue / blood
  • Fatigue / drug therapy
  • Fatigue / physiopathology
  • Heart Rate / drug effects
  • Heart Rate / physiology
  • Humans
  • Magnesium / administration & dosage
  • Magnesium / blood
  • Magnesium / pharmacology*
  • Male
  • Norepinephrine / blood
  • Sleep Deprivation / physiology*
  • Time Factors
  • Treatment Outcome


  • Magnesium
  • Calcium
  • Norepinephrine