Low molecular weight heparin-induced skin necrosis occurring distant from injection sites and without thrombocytopenia

J Intern Med. 1998 Apr;243(4):313-5. doi: 10.1046/j.1365-2796.1998.00304.x.


In this paper we report a case of 76-year-old white male patient with skin necrosis induced by subcutaneous prophylactic administration of low-molecular-weight heparin (LMWH). Skin necrosis occurred distant from heparin injection sites and without concomitant thrombocytopenia. This is the first reported case presenting these clinical findings.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Fibrinolytic Agents / adverse effects*
  • Heparin, Low-Molecular-Weight / adverse effects*
  • Humans
  • Injections, Subcutaneous
  • Male
  • Necrosis
  • Skin / drug effects*
  • Skin / pathology*
  • Thrombocytopenia


  • Fibrinolytic Agents
  • Heparin, Low-Molecular-Weight