Clostridium difficile colitis associated with a 'triple' regimen, containing clarithromycin and metronidazole, to eradicate Helicobacter pylori

J Intern Med. 1998 Mar;243(3):251-3. doi: 10.1046/j.1365-2796.1998.00272.x.


We describe a 54-year-old man with Helicobacter pylori (+) duodenal ulcer who developed Clostridium difficile associated colitis, 5 days after commencing a 'triple' regimen consisting of omeprazole 20 mg b.d., metronidazole 500 mg b.d. and clarithromycin 500 mg b.d., to eradicate H. pylori. Despite the fact that oral metronidazole did not prevent the disease, the patient did well after treatment with oral metronidazole plus a yeast preparation (Saccharomyces bulardii). No relapse occurred.

Publication types

  • Case Reports

MeSH terms

  • Anti-Ulcer Agents / therapeutic use
  • Clarithromycin / therapeutic use
  • Drug Therapy, Combination / adverse effects*
  • Drug Therapy, Combination / therapeutic use
  • Duodenal Ulcer / drug therapy*
  • Duodenal Ulcer / microbiology
  • Enterocolitis, Pseudomembranous / etiology*
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori*
  • Humans
  • Male
  • Metronidazole / therapeutic use
  • Middle Aged
  • Omeprazole / therapeutic use


  • Anti-Ulcer Agents
  • Metronidazole
  • Clarithromycin
  • Omeprazole