Effects of Hemerocallis on sleep in mice

Psychiatry Clin Neurosci. 1998 Apr;52(2):136-7. doi: 10.1111/j.1440-1819.1998.tb00992.x.


Freeze-dried flowers of the Akinowasuregusa (Hemerocallis fulva L. var. sempervirona M. Hotta), a Hemerocallis genus of the lily family, were fed to C57BL strain mice. The slow wave sleep and paradoxical sleep of the Hemerocallis-treated group increased during the dark period. The differences between the control group and the Hemerocallis-treated group were significant (P < 0.05). The Hemerocallis feeding did not cause a change in sleep time during the light period. As a result, there was no significant change in the sleep-time percentage over a 24-h period.

MeSH terms

  • Administration, Oral
  • Animals
  • Circadian Rhythm / drug effects
  • Hypnotics and Sedatives / pharmacology*
  • Liliaceae*
  • Mice
  • Mice, Inbred Strains
  • Plants, Medicinal*
  • Polysomnography
  • Sleep Stages / drug effects*


  • Hypnotics and Sedatives