Abstract
For insomniac patients, sleeping drugs are used: in addition, concomitant therapy with other drugs has been tried in an effort to prevent a decrease in the effects due to long-term continuous use. This report presents the results of a study on the sleeping effects in nine aged patients with insomnia associated with cerebrovascular and noncerebrovascular disorders who received concomitant therapy with Zopiclone and Aniracetam. The treatment in 7/9 cases (78%) was found to be effective, showing more than 50% prolongation of sleeping time, and in two cases (22%) was found to be ineffective. We discuss the mechanism of action referring to the literature.
MeSH terms
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Aged
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Alzheimer Disease / drug therapy*
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Atrophy
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Azabicyclo Compounds
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Cerebral Cortex / pathology*
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Cerebral Infarction / drug therapy*
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Drug Therapy, Combination
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Female
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Humans
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Hypnotics and Sedatives / administration & dosage*
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Hypnotics and Sedatives / adverse effects
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Male
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Nootropic Agents / administration & dosage*
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Nootropic Agents / adverse effects
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Parkinson Disease / drug therapy*
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Piperazines / administration & dosage*
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Piperazines / adverse effects
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Polysomnography
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Pyrrolidinones / administration & dosage*
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Pyrrolidinones / adverse effects
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Sleep Initiation and Maintenance Disorders / drug therapy*
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Sleep Stages / drug effects
Substances
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Azabicyclo Compounds
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Hypnotics and Sedatives
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Nootropic Agents
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Piperazines
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Pyrrolidinones
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zopiclone
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aniracetam