[Fibrinogen as independent risk factor for ischemic stroke]

Arq Neuropsiquiatr. 1997 Dec;55(4):737-40. doi: 10.1590/s0004-282x1997000500009.
[Article in Portuguese]


We have studied fibrinogen levels (Clauss technique) in atherothrombotic ischemic stroke patients, in order to determine its role as a thrombogenic risk factor. Twenty nine patients (20 men and 9 women) between 25 and 79 years old were studied; they all have had a atherothrombotic stroke. They were classified into two groups according to the result of their carotid doppler ultrasonography: gl-without carotid flow reduction (n = 19) and g2-with carotid flow reduction (n = 10). The fibrinogen mean value was 269 mg/dl in gl and 353 mg/dl in g2. There were 47% of patients in gl and 80% of patients in g2 who presented levels > 300 mg/dl. The proportions of the groups were significantly different (p < 0.05). Considering the epidemiological value of 300 mg/dl, we conclude that the fibrinogen can be an independent risk factor for ischemic atherothrombotic stroke, specially in those whose carotid flow is reduced.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Brain Ischemia / blood
  • Cerebrovascular Disorders / blood
  • Cerebrovascular Disorders / epidemiology*
  • Female
  • Fibrinogen / analysis*
  • Fibrinogen / physiology
  • Humans
  • Intracranial Embolism and Thrombosis / blood
  • Male
  • Middle Aged
  • Risk Factors
  • Statistics, Nonparametric


  • Fibrinogen