Sustained improvement in blood lipids, coagulation, and fibrinolysis after major weight loss in obese subjects

Eur J Clin Nutr. 1998 May;52(5):329-33. doi: 10.1038/sj.ejcn.1600558.


Objective: To study whether major weight loss causes sustained improvement in blood lipids and haemostatic profile in obese subjects, and to compare the influence of two different slimming and maintenance regimens.

Design: Two-stranded randomized intervention study.

Setting: University Department.

Subjects: Thirty-six out of 43 obese patients recruited from out-patient waiting list completed the study.

Interventions: Weight loss was achieved by very low energy formula diet (2 MJ/d for 8 weeks, n=18), or low-energy conventional diet (5 MJ/d for 17 weeks, n=18), both combined with anorectic compound. Participants were re-randomized to consume low fat diet ad libitum (n=16), or energy-restricted diet (n=20) for weight maintenance during 24 weeks.

Main outcome measures: Plasma lipids, fibrinogen, factor VII coagulant activity (FVIIc), and plasminogen activator inhibitor type 1 (PAI-1) antigen.

Results: Weight loss averaged 13.6 kg (95% CI: 12.3-14.9 kg). After 24 weeks' weight maintenance, plasma total cholesterol was 9% lower, high density lipoprotein cholesterol 5% higher, triglycerides 30% lower, FVIIc 12% lower, fibrinogen 6% lower, and PAI-1 antigen 34% lower than at baseline (all changes highly significant). There were no significant differences between slimming or maintenance regimens.

Conclusions: Major weight loss is associated with sustained and marked improvements in blood lipids and hemostatic profile, irrespective of the tested slimming and maintenance regimens.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Coagulation*
  • Body Mass Index
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Factor VII / metabolism
  • Female
  • Fibrinogen / metabolism
  • Fibrinolysis*
  • Humans
  • Lipids / blood*
  • Male
  • Middle Aged
  • Obesity / diet therapy*
  • Plasminogen Activator Inhibitor 1 / metabolism
  • Triglycerides / blood
  • Weight Loss*


  • Cholesterol, HDL
  • Lipids
  • Plasminogen Activator Inhibitor 1
  • Triglycerides
  • Factor VII
  • Fibrinogen
  • Cholesterol