Antiadhesive effects of xylitol on otopathogenic bacteria

J Antimicrob Chemother. 1998 May;41(5):563-5. doi: 10.1093/jac/41.5.563.


The exposure of either epithelial cells or pneumococci or both to 5% xylitol reduced the adherence of pneumococci. Exposure of epithelial cells or bacteria alone to xylitol did not reduce the adherence of Haemophilus influenzae, although the exposure of both cells and bacteria to xylitol reduced the adherence significantly. The adherence of Moraxella catarrhalis remained low irrespective of the exposure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Adhesion / drug effects*
  • Epithelial Cells / drug effects
  • Epithelial Cells / physiology
  • Haemophilus influenzae / drug effects*
  • Haemophilus influenzae / physiology
  • Humans
  • In Vitro Techniques
  • Moraxella catarrhalis / drug effects*
  • Moraxella catarrhalis / physiology
  • Oropharynx / cytology
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / physiology
  • Xylitol / pharmacology*


  • Xylitol