Aluminum alters intracellular calcium homeostasis in vitro

Biochim Biophys Acta. 1998 Apr 28;1406(3):315-20. doi: 10.1016/s0925-4439(98)00018-0.

Abstract

The present paper reports data regarding the influence of aluminum, at micromolar concentrations, on intracellular calcium homeostasis. Al3+ modifies Ca2+ uptake in the endoplasmic reticulum (ER), accelerates Ca2+ release from mitochondria and strongly inhibits Ca2+-ATPase activity with a consequent high-level calcium accumulation inside the cell. These results suggest that Al3+ neurotoxicity may be related to an alteration of the intracellular calcium regulatory system.

MeSH terms

  • Aluminum / chemistry*
  • Aluminum / metabolism
  • Animals
  • Biological Transport, Active
  • Calcium / metabolism*
  • Calcium-Transporting ATPases / antagonists & inhibitors
  • Calcium-Transporting ATPases / metabolism
  • Endoplasmic Reticulum / enzymology
  • Endoplasmic Reticulum / metabolism
  • Enzyme Inhibitors / chemistry
  • Fluorescent Dyes / metabolism
  • Homeostasis
  • Intracellular Fluid / enzymology
  • Intracellular Fluid / metabolism*
  • Mitochondria, Liver / enzymology
  • Mitochondria, Liver / metabolism
  • Organic Chemicals
  • Rats
  • Rats, Wistar
  • Thapsigargin / chemistry

Substances

  • Enzyme Inhibitors
  • Fluorescent Dyes
  • Organic Chemicals
  • calcium green
  • Thapsigargin
  • Aluminum
  • Calcium-Transporting ATPases
  • Calcium