The use of solid physical models for the study of macromolecular assembly

Curr Opin Struct Biol. 1998 Apr;8(2):202-8. doi: 10.1016/s0959-440x(98)80039-0.

Abstract

The use of modern technology in the construction of accurate solid macromolecular models based on atomic coordinates and electron density functions has led us to re-examine the usefulness of physical models as tools for understanding molecular assembly and for designing detailed experimental and computational studies of the assembly process. Recent developments include the construction of new models, which have provided insights into the assembly of viruses and light harvesting complexes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Biomedical Engineering
  • Capsid / chemistry
  • Electrochemistry
  • Macromolecular Substances*
  • Models, Molecular*
  • Photosynthetic Reaction Center Complex Proteins / chemistry
  • Protein Conformation
  • Viruses / chemistry

Substances

  • Macromolecular Substances
  • Photosynthetic Reaction Center Complex Proteins