Effects of 18-methoxycoronaridine on acute signs of morphine withdrawal in rats

Neuroreport. 1998 May 11;9(7):1283-5. doi: 10.1097/00001756-199805110-00004.

Abstract

Ibogaine, an alkaloid found in the root bark of the African shrub Tabernanthe iboga, has been claimed to interrupt opioid dependence in humans; in animals, it has been shown to inhibit morphine self-administration and to attenuate signs of morphine withdrawal. However, ibogaine has some neurotoxicity, and because of this, efficacious and safer congeners of ibogaine have been sought, 18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener, has been shown, in animals, to mimic the effects of ibogaine on morphine self-administration without producing any ibogaine-like neurotoxiticity. In the present study, 18-MC was shown to attenuate five of seven signs of morphine withdrawal in rats. The data suggest that 18-MC will ameliorate symptoms of opioid dependence in humans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Animals
  • Female
  • Hallucinogens / pharmacology
  • Humans
  • Ibogaine / analogs & derivatives*
  • Ibogaine / pharmacology
  • Morphine Dependence / physiopathology*
  • Rats
  • Rats, Sprague-Dawley
  • Stereotyped Behavior / drug effects
  • Substance Withdrawal Syndrome / physiopathology*
  • Substance Withdrawal Syndrome / prevention & control*
  • Weight Loss / drug effects

Substances

  • Hallucinogens
  • Ibogaine
  • 18-methoxycoronaridine