Abstract
Developing neurons depend on target-derived trophic factors for survival in vivo and in vitro, which also decrease the activity of c-Jun N-terminal kinase (JNK). We have recently described a survival-promoting effect of inhibitors of cyclin-dependent kinases and JNK on chick peripheral embryonic neurons. Here, we report that the small trophic molecule CEP-1347/KT7515, which has been shown to inhibit the JNK signalling pathway, can promote long term-survival of cultured chick embryonic dorsal root ganglion, sympathetic, ciliary and motor neurons. Because of their pharmacological properties, small trophic molecules such as CEP-1347/KT7515 might be of interest for the treatment of neurodegenerative disorders.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors*
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Cell Survival / drug effects
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Cells, Cultured
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Chick Embryo
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Enzyme Inhibitors / pharmacology*
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Ganglia, Parasympathetic / cytology
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Ganglia, Spinal / cytology
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Ganglia, Sympathetic / cytology
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JNK Mitogen-Activated Protein Kinases
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Mitogen-Activated Protein Kinases*
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Motor Neurons / cytology*
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Motor Neurons / drug effects
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Motor Neurons / physiology
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Neurons / cytology*
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Neurons / drug effects
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Neurons / physiology
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Signal Transduction / drug effects
Substances
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Enzyme Inhibitors
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Calcium-Calmodulin-Dependent Protein Kinases
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JNK Mitogen-Activated Protein Kinases
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Mitogen-Activated Protein Kinases