Massive lymphadenopathy and airway obstruction in a child with Kawasaki disease: success with pulse steroid therapy

J Rheumatol. 1998 Jun;25(6):1215-7.

Abstract

Kawasaki disease (KD) is an acute, febrile, self-limited, multisystem vasculitis that almost exclusively affects young children. We describe a 4-year-old girl with intravenous immunoglobulin (IVIG) resistant KD who developed massive cervical lymphadenopathy and severe respiratory distress. Treatment with intravenous pulse methylprednisolone led to dramatic resolution of her symptoms. We conclude that pulse steroid therapy should be considered in patients with KD complicated by massive lymphadenopathy with life threatening airway obstruction and/or IVIG resistant disease.

Publication types

  • Case Reports

MeSH terms

  • Airway Obstruction / complications*
  • Airway Obstruction / drug therapy
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / therapeutic use*
  • Child, Preschool
  • Female
  • Humans
  • Injections, Intravenous
  • Lymphatic Diseases / complications*
  • Lymphatic Diseases / drug therapy
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / therapeutic use*
  • Mucocutaneous Lymph Node Syndrome / complications*
  • Mucocutaneous Lymph Node Syndrome / drug therapy
  • Neck / diagnostic imaging
  • Neck / pathology
  • Tomography, X-Ray Computed

Substances

  • Anti-Inflammatory Agents
  • Methylprednisolone