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Review
, 280 (5371), 1884-8

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

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Review

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

R Wyatt et al. Science.

Abstract

The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1 envelope glycoproteins and, ultimately, aid in HIV-1 vaccine development.

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