Alpha tocopherol in CSF of subjects taking high-dose vitamin E in the DATATOP study. Parkinson Study Group

Neurology. 1998 Jun;50(6):1900-2. doi: 10.1212/wnl.50.6.1900.

Abstract

Alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76+/-10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antioxidants / therapeutic use
  • Antiparkinson Agents / therapeutic use
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Humans
  • Parkinson Disease / drug therapy*
  • Selegiline / therapeutic use
  • Vitamin E / administration & dosage*
  • Vitamin E / cerebrospinal fluid*
  • Vitamin E / therapeutic use

Substances

  • Antioxidants
  • Antiparkinson Agents
  • Vitamin E
  • Selegiline