Abstract
Alpha-Tocopherol concentrations were determined in the CSF of patients with early untreated Parkinson's disease receiving 2,000 IU vitamin E orally per day. After treatment the concentrations increased significantly (p < 0.001) by 76+/-10 (SE)%. The net increases in CSF alpha-tocopherol concentrations after treatment showed a significant positive correlation with the number of days of vitamin E ingestion (p < 0.001). Thus, high-dose vitamin E treatment results in elevating CSF vitamin E levels and possibly brain vitamin E levels.
Publication types
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Clinical Trial
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antioxidants / therapeutic use
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Antiparkinson Agents / therapeutic use
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Dose-Response Relationship, Drug
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Double-Blind Method
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Humans
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Parkinson Disease / drug therapy*
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Selegiline / therapeutic use
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Vitamin E / administration & dosage*
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Vitamin E / cerebrospinal fluid*
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Vitamin E / therapeutic use
Substances
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Antioxidants
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Antiparkinson Agents
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Vitamin E
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Selegiline