Computational fluid dynamics was used to model flow past multiple adherent leukocytes in postcapillary size vessels. A finite-element package was used to solve the Navier-Stokes equations for low Reynolds number flow of a Newtonian fluid past spheres adhering to the wall of a cylindrical vessel. We determined the effects of sphere number, relative geometry, and spacing on the flow resistance in the vessel and the fluid flow drag force acting to sweep the sphere off the vessel wall. The computations show that when adherent leukocytes are aligned on the same side of the vessel, the drag force on each of the interacting leukocytes is less than the drag force on an isolated adherent leukocyte and can decrease by up to 50%. The magnitude of the reduction depends on the ratio of leukocyte to blood vessel diameter and distance between adherent leukocytes. However, there is an increase in the drag force when leukocytes adhere to opposite sides of the vessel wall. The increase in resistance generated by adherent leukocytes in vessels of various sizes is calculated from the computational results. The resistance increases with decreasing vessel size and is most pronounced when leukocytes adhere to opposite sides of the vessel.