HMG-CoA Reductase Inhibitors Pravastatin and Simvastatin Inhibit Human B-lymphocyte Activation

Transplant Proc. 1998 Jun;30(4):992-5. doi: 10.1016/s0041-1345(98)00123-7.

MeSH terms

  • Antibodies, Monoclonal / pharmacology
  • B-Lymphocytes / drug effects
  • B-Lymphocytes / immunology*
  • CD40 Antigens / immunology
  • CD40 Antigens / physiology
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Interleukin-4 / pharmacology
  • Kinetics
  • Lymphocyte Activation / drug effects*
  • Mitogens
  • Palatine Tonsil
  • Pravastatin / pharmacology*
  • Recombinant Proteins / pharmacology
  • Simvastatin / pharmacology*

Substances

  • Antibodies, Monoclonal
  • CD40 Antigens
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Mitogens
  • Recombinant Proteins
  • Interleukin-4
  • Simvastatin
  • Pravastatin