Transcription: gene control by targeted histone acetylation

Curr Biol. 1998 Jun 4;8(12):R422-4. doi: 10.1016/s0960-9822(98)70268-4.

Abstract

A transcriptional regulator in yeast, Gcn5p, activates transcription by targeted acetylation of specific lysine residues in the amino-terminal tails of histones. This targeted modification is restricted to nucleosomes assembled on the promoters of Gcn5p-responsive genes.

Publication types

  • Review

MeSH terms

  • Acetylation
  • Acetyltransferases / metabolism*
  • Animals
  • DNA-Binding Proteins*
  • Fungal Proteins / metabolism*
  • Histones / genetics
  • Histones / metabolism*
  • Humans
  • Protein Kinases / metabolism*
  • Saccharomyces cerevisiae / enzymology*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae Proteins*
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • Fungal Proteins
  • Histones
  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Protein Kinases