Long-lived Plasma Cells: A Mechanism for Maintaining Persistent Antibody Production

Curr Opin Immunol. 1998 Jun;10(3):252-8. doi: 10.1016/s0952-7915(98)80162-3.

Abstract

Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibody responses.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody Formation*
  • Antigen-Antibody Complex / immunology
  • B-Lymphocyte Subsets / immunology
  • Cell Movement
  • Cellular Senescence
  • Chronic Disease
  • Cross Reactions
  • Dendritic Cells / immunology
  • Humans
  • Immunoglobulin Idiotypes / immunology
  • Immunologic Memory / immunology*
  • Lymphocyte Activation
  • Mice
  • Models, Immunological
  • Plasma Cells / cytology*
  • Plasma Cells / immunology
  • Vaccination

Substances

  • Antigen-Antibody Complex
  • Immunoglobulin Idiotypes