Chemokines, lymphocytes and viruses: what goes around, comes around

Curr Opin Immunol. 1998 Jun;10(3):265-70. doi: 10.1016/s0952-7915(98)80164-7.

Abstract

Chemokines are believed to be the long-sought soluble mediators of selective lymphocyte recruitment. As most selectin-integrin interactions are nonselective, it is thought that the discrimination seen during lymphocyte infiltration into tissues is brought about by the actions of distinct chemokines. Developments over the past year have demonstrated the expanding roles of these factors in lymphocyte chemoattraction, normal trafficking, and viral immunity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion / drug effects
  • Cell Adhesion Molecules / physiology
  • Chemokines / antagonists & inhibitors
  • Chemokines / physiology*
  • Chemotaxis, Leukocyte / physiology*
  • HIV Infections / immunology
  • HIV Infections / pathology
  • Humans
  • Inflammation / immunology
  • Inflammation / pathology
  • Integrins / physiology
  • Lymphocyte Subsets / cytology
  • Lymphocyte Subsets / immunology*
  • Models, Immunological
  • Poxviridae / physiology
  • Poxviridae Infections / immunology
  • Poxviridae Infections / pathology
  • Receptors, Chemokine / drug effects
  • Receptors, Chemokine / physiology
  • Th2 Cells / cytology
  • Th2 Cells / immunology
  • Virus Diseases / immunology*
  • Virus Diseases / pathology

Substances

  • Cell Adhesion Molecules
  • Chemokines
  • Integrins
  • Receptors, Chemokine