JAK/STAT signaling by cytokine receptors

Curr Opin Immunol. 1998 Jun;10(3):271-8. doi: 10.1016/s0952-7915(98)80165-9.

Abstract

The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicated selected STAT factors as predominant mediators for a limited number of lymphokines. This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Transformation, Neoplastic
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Dimerization
  • Feedback
  • Gene Expression Regulation / drug effects
  • Gene Expression Regulation / physiology*
  • Gene Targeting
  • Genes, Lethal
  • Interferons / physiology
  • Mice
  • Mice, Knockout
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Protein-Tyrosine Kinases / deficiency
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / physiology*
  • Receptors, Cytokine / drug effects
  • Receptors, Cytokine / physiology*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology*
  • Trans-Activators / deficiency
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • src Homology Domains

Substances

  • DNA-Binding Proteins
  • Receptors, Cytokine
  • Trans-Activators
  • Interferons
  • Protein-Tyrosine Kinases