Adaptor proteins in lymphocyte antigen-receptor signaling

Curr Opin Immunol. 1998 Jun;10(3):337-44. doi: 10.1016/s0952-7915(98)80173-8.

Abstract

Adaptor molecules, proteins that possess no intrinsic enzymatic function, but which mediate protein-protein interactions, have a critical role in integrating signal transduction pathways following engagement of cell-surface receptors. Several newly described adaptor molecules have been shown to serve important functions in the regulation of signaling events initiated by lymphocyte antigen receptors. Understanding how these adaptor proteins function to modulate signaling cascades will provide important insights into the complex biology of lymphocyte activation.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • B-Lymphocytes / immunology
  • Carrier Proteins / physiology
  • GRB2 Adaptor Protein
  • Humans
  • Lymphocyte Activation / physiology*
  • Membrane Proteins*
  • Models, Immunological
  • Nuclear Proteins / physiology
  • Phosphoproteins / physiology
  • Proteins / physiology
  • Receptor-CD3 Complex, Antigen, T-Cell / immunology
  • Receptors, Antigen, B-Cell / immunology*
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / physiology*
  • T-Lymphocytes / immunology
  • src Homology Domains / physiology

Substances

  • Adaptor Proteins, Signal Transducing
  • CRKL protein
  • Carrier Proteins
  • FYB1 protein, human
  • GRB2 Adaptor Protein
  • GRB2 protein, human
  • LAT protein, human
  • Membrane Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • Proteins
  • Receptor-CD3 Complex, Antigen, T-Cell
  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell
  • SKAP1 protein, human
  • SLP-76 signal Transducing adaptor proteins