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Review
. 1998 Jun;10(3):353-9.
doi: 10.1016/s0952-7915(98)80175-1.

The Regulation and Roles of Rel/NF-kappa B Transcription Factors During Lymphocyte Activation

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Review

The Regulation and Roles of Rel/NF-kappa B Transcription Factors During Lymphocyte Activation

S Gerondakis et al. Curr Opin Immunol. .

Abstract

The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-kappa B (NF-kappa B) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-kappa B family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.

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